WASF2

WASF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2A40
Identifiers
Aliases	WASF2, IMD2, SCAR2, WASF4, WAVE2, dJ393P12.2, WAS protein family member 2, WASP family member 2
External IDs	OMIM: 605875; MGI: 1098641; HomoloGene: 86743; GeneCards: WASF2; OMA:WASF2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,490,167 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,927,067 bp
RNA expression pattern
	Top expressed in
	nipple; ; skin of arm; ; tendon of biceps brachii; ; saphenous vein; ; pylorus; ; lower lobe of lung; ; cardia; ; mucosa of pharynx; ; trachea; ; lactiferous duct;
	Top expressed in
	zygote; ; left lung lobe; ; tibiofemoral joint; ; secondary oocyte; ; vas deferens; ; gastrula; ; Gonadal ridge; ; mesenteric lymph nodes; ; submandibular gland; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; protein binding; actin binding; SH3 domain binding; cadherin binding; protein kinase A binding;
Cellular component	cytoplasm; cytosol; cell projection; SCAR complex; cell-cell junction; ruffle; intracellular anatomical structure; early endosome; actin cytoskeleton; extracellular exosome; cytoskeleton; lamellipodium; protein-containing complex; synapse;
Biological process	megakaryocyte development; endocytosis; Fc-gamma receptor signaling pathway involved in phagocytosis; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; actin filament-based movement; vascular endothelial growth factor receptor signaling pathway; angiogenesis; Rac protein signal transduction; viral process; positive regulation of lamellipodium assembly; negative regulation of stress fiber assembly; ameboidal-type cell migration; lamellipodium morphogenesis; actin cytoskeleton organization; lamellipodium assembly; postsynaptic actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	10163
	242687
	ENSG00000158195
	ENSMUSG00000028868
	Q9Y6W5
	Q8BH43
	NM_006990; NM_001201404
	NM_153423
	NP_001188333; NP_008921
	NP_700472
	Wikidata
View/Edit Human	View/Edit Mouse

Wiskott–Aldrich syndrome protein family member 2 is a protein that in humans is encoded by the WASF2 gene.

This gene encodes a member of the Wiskott–Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X.