WASF3

WASF3
Identifiers
Aliases	WASF3, Brush-1, SCAR3, WAVE3, WAS protein family member 3, WASP family member 3
External IDs	OMIM: 605068; MGI: 2658986; HomoloGene: 68527; GeneCards: WASF3; OMA:WASF3 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	26,688,948 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	146,410,425 bp
RNA expression pattern
	Top expressed in
	pars compacta; ; pars reticulata; ; paraflocculus of cerebellum; ; lateral nuclear group of thalamus; ; orbitofrontal cortex; ; cerebellar vermis; ; postcentral gyrus; ; external globus pallidus; ; Brodmann area 46; ; dorsal motor nucleus of vagus nerve;
	Top expressed in
	ventral tegmental area; ; neural layer of retina; ; lobe of cerebellum; ; cerebellar vermis; ; dorsomedial hypothalamic nucleus; ; mammillary body; ; globus pallidus; ; lateral hypothalamus; ; lateral septal nucleus; ; deep cerebellar nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding;
Cellular component	cytoplasm; extracellular exosome; cytoskeleton; lamellipodium; postsynapse; glutamatergic synapse;
Biological process	positive regulation of myelination; oligodendrocyte development; actin filament polymerization; cytoskeleton organization; actin cytoskeleton organization; lamellipodium assembly; regulation of cell shape; protein-containing complex assembly; modification of postsynaptic actin cytoskeleton;
	Sources:Amigo / QuickGO
Orthologs
	10810
	245880
	ENSG00000132970
	ENSMUSG00000029636
	Q9UPY6; Q5T8P4
	Q8VHI6
	NM_001291965; NM_006646
	NM_145155
	NP_001278894; NP_006637; NP_006637.2
	NP_660137
	Wikidata
View/Edit Human	View/Edit Mouse

Wiskott–Aldrich syndrome protein family member 3 is a protein that in humans is encoded by the WASF3 gene.

This gene encodes a member of the Wiskott–Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to transduce signals that involve changes in cell shape, motility or function.