WASHC2C

WASHC2C
Identifiers
Aliases	WASHC2C, FAM21A, VPEF, FAM21C, family with sequence similarity 21 member C, WASH complex subunit 2C
External IDs	OMIM: 613631; MGI: 106463; HomoloGene: 41686; GeneCards: WASHC2C; OMA:WASHC2C - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	45,792,961 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	116,239,647 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; monocyte; ; Achilles tendon; ; transverse colon; ; rectum; ; right hemisphere of cerebellum; ; endometrium; ; lymph node; ; granulocyte; ; spleen;
	Top expressed in
	cerebellar vermis; ; lobe of cerebellum; ; internal carotid artery; ; external carotid artery; ; Paneth cell; ; substantia nigra; ; fossa; ; endothelial cell of lymphatic vessel; ; motor neuron; ; medullary collecting duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3,4,5-trisphosphate binding; lipid binding; retromer complex binding;
Cellular component	early endosome membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; retromer complex; early endosome; nucleolus; endosome; WASH complex; cytosol;
Biological process	negative regulation of barbed-end actin filament capping; retrograde transport, endosome to Golgi; protein transport; regulation of substrate adhesion-dependent cell spreading; protein localization to endosome;
	Sources:Amigo / QuickGO
Orthologs
	253725
	28006
	ENSG00000172661
	ENSMUSG00000024104
	Q9Y4E1
	Q6PGL7
	NM_001169106; NM_001169107; NM_015262; NM_001330074
	NM_026585
NP_001162577; NP_001162578; NP_001317003; NP_056077; NP_001354322;
	NP_001354323; NP_001354324; NP_001354325; NP_001354326; NP_001354327; NP_001354328; NP_001354329; NP_001354330; NP_001354331; NP_001354332; NP_001354333; NP_001354334; NP_001354335; NP_001354336; NP_001354337; NP_001354338; NP_001354339; NP_001354340; NP_001354341; NP_001354342; NP_001354343; NP_001354344; NP_001354345
	NP_080861
	Wikidata
View/Edit Human	View/Edit Mouse

WASH complex subunit 2C is a protein that in humans is encoded by the WASHC2C gene. WASHC2C, also known as WASHCAP, VPEF, FAM21A, or FAM21C, is expressed ubiquitously. WASHC2C is intracellular and is mainly in the cytosol associated with vesicles. The protein has a low immune cell, human brain regional, and a low tissue specificity. Some diseases that the protein are associated with are Vaccinia and Transient Tic Disorder.