WAY-100635

WAY-100635
Identifiers
	IUPAC name N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridyl)cyclohexanecarboxamide;
CAS Number	146714-97-8 ;
PubChem CID	5684;
IUPHAR/BPS	80;
ChemSpider	5482 ;
UNII	8S48P899NE;
ChEMBL	ChEMBL31354 ;
CompTox Dashboard (EPA)	DTXSID20167467 ;
Chemical and physical data
Formula	C25H34N4O2
Molar mass	422.573 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4;
	InChI InChI=1S/C25H34N4O2/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3 ; Key:SBPRIAGPYFYCRT-UHFFFAOYSA-N ;
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WAY-100635 is a piperazine drug and research chemical widely used in scientific studies. It was originally believed to act as a selective 5-HT_1A receptor antagonist, but subsequent research showed that it also acts as potent full agonist at the D₄ receptor. It is sometimes referred to as a silent antagonist at the former receptor. It is closely related to WAY-100135.

In light of its dopaminergic activity, conclusions drawn from studies that employ WAY-100635 as a selective 5-HT_1A antagonist may need to be re-evaluated.

Identifiers

IUPAC name N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridyl)cyclohexanecarboxamide
CAS Number	146714-97-8^Y
PubChem CID	5684
IUPHAR/BPS	80
ChemSpider	5482^N
UNII	8S48P899NE
ChEMBL	ChEMBL31354^N
CompTox Dashboard (EPA)	DTXSID20167467
Chemical and physical data
Formula	C₂₅H₃₄N₄O₂
Molar mass	422.573 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4
InChI InChI=1S/C25H34N4O2/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3^N Key:SBPRIAGPYFYCRT-UHFFFAOYSA-N^N
^NY (what is this?) (verify)