WBP2

WBP2
Identifiers
Aliases	WBP2, WBP-2, GRAMD6, WW domain binding protein 2, DFNB107
External IDs	OMIM: 606962; MGI: 104709; HomoloGene: 32160; GeneCards: WBP2; OMA:WBP2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	75,856,507 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,977,821 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; right hemisphere of cerebellum; ; prefrontal cortex; ; C1 segment; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	primary visual cortex; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; perirhinal cortex; ; cerebellar cortex; ; entorhinal cortex; ; right kidney; ; granulocyte; ; CA3 field;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chromatin DNA binding; protein binding; RNA polymerase II core promoter sequence-specific DNA binding; transcription coactivator activity; estrogen receptor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleus; cytoplasm;
Biological process	positive regulation of histone H3-K14 acetylation; positive regulation of transcription by RNA polymerase II; establishment of protein localization; epigenetic maintenance of chromatin in transcription-competent conformation; cellular response to estrogen stimulus; response to progesterone; positive regulation of intracellular estrogen receptor signaling pathway; response to estrogen; progesterone receptor signaling pathway; transcription by RNA polymerase II; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	23558
	22378
	ENSG00000132471
	ENSMUSG00000034341
	Q969T9
	P97765
	NM_012478; NM_001330499; NM_001348170
	NM_016852; NM_001347642; NM_001361446
	NP_001317428; NP_036610; NP_001335099
	NP_001334571; NP_058548; NP_001348375
	Wikidata
View/Edit Human	View/Edit Mouse

WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene.

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.