WDR1

WDR1
Identifiers
Aliases	WDR1, AIP1, HEL-S-52, NORI-1, WD repeat domain 1, PFITS
External IDs	OMIM: 604734; MGI: 1337100; HomoloGene: 6628; GeneCards: WDR1; OMA:WDR1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	10,116,949 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	38,720,564 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; smooth muscle tissue; ; right coronary artery; ; body of uterus; ; saphenous vein; ; stromal cell of endometrium; ; parotid gland; ; thoracic aorta; ; mucosa of sigmoid colon;
	Top expressed in
	ankle joint; ; granulocyte; ; mesenteric lymph nodes; ; stroma of bone marrow; ; transitional epithelium of urinary bladder; ; corneal stroma; ; mucous cell of stomach; ; tibiofemoral joint; ; left colon; ; molar;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	actin binding; actin filament binding;
Cellular component	extracellular region; myelin sheath; podosome; cell junction; cell projection; extracellular exosome; cytoskeleton; actin filament; cell-cell junction; cytoplasm; cytosol; cortical actin cytoskeleton; plasma membrane;
Biological process	platelet degranulation; hearing; actin cytoskeleton organization; regulation of ventricular cardiac muscle cell membrane repolarization; regulation of oligodendrocyte differentiation; maintenance of epithelial cell apical/basal polarity; apical junction assembly; regulation of actin filament depolymerization; neutrophil mediated immunity; regulation of cell shape; actin filament fragmentation; platelet formation; positive regulation of actin filament depolymerization; cortical cytoskeleton organization; locomotion; establishment of planar polarity of follicular epithelium; sarcomere organization; neutrophil migration; actin filament depolymerization;
	Sources:Amigo / QuickGO
Orthologs
	9948
	22388
	ENSG00000071127
	ENSMUSG00000005103
	O75083
	O88342
	NM_005112; NM_017491
	NM_011715
	NP_005103; NP_059830
	NP_035845
	Wikidata
View/Edit Human	View/Edit Mouse

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.