WDR12

WDR12
Identifiers
Aliases	WDR12, YTM1, WD repeat domain 12
External IDs	OMIM: 616620; MGI: 1927241; HomoloGene: 10098; GeneCards: WDR12; OMA:WDR12 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	203,014,798 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	60,137,804 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; secondary oocyte; ; stromal cell of endometrium; ; gonad; ; buccal mucosa cell; ; mucosa of transverse colon; ; right adrenal gland; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	spermatid; ; spermatocyte; ; embryo; ; Rostral migratory stream; ; embryo; ; morula; ; blastocyst; ; epiblast; ; ventricular zone; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ribonucleoprotein complex binding;
Cellular component	nucleolus; nucleus; PeBoW complex; nucleoplasm; preribosome, large subunit precursor;
Biological process	Notch signaling pathway; cell population proliferation; ribosome biogenesis; rRNA processing; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ribosomal large subunit biogenesis;
	Sources:Amigo / QuickGO
Orthologs
	55759
	57750
	ENSG00000138442
	ENSMUSG00000026019
	Q9GZL7
	Q9JJA4
	NM_018256; NM_001371664
	NM_001199060; NM_001199061; NM_021312
	NP_060726; NP_001358593
	NP_001185989; NP_001185990; NP_067287
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosome biogenesis protein WDR12 is a protein that in humans is encoded by the WDR12 gene on chromosome 2. It is ubiquitously expressed in many tissues and cell types. WDR12 participates in ribosome biogenesis and cell proliferation as a component of the PeBoW complex. This protein is associated with cardiovascular diseases such as coronary artery disease and myocardial infarction. The PCSK9 gene also contains one of 27 loci associated with increased risk of coronary artery disease.