WFDC2

WFDC2
Identifiers
Aliases	WFDC2, EDDM4, HE4, WAP5, dJ461P17.6, WAP four-disulfide core domain 2
External IDs	OMIM: 617548; MGI: 1914951; HomoloGene: 4450; GeneCards: WFDC2; OMA:WFDC2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,481,532 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,410,430 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; nasal epithelium; ; right uterine tube; ; epithelium of bronchus; ; bronchial epithelial cell; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; palpebral conjunctiva; ; corpus epididymis; ; trachea;
	Top expressed in
	right lung lobe; ; transitional epithelium of urinary bladder; ; left lung; ; left colon; ; cervix; ; olfactory epithelium; ; left lung lobe; ; medullary collecting duct; ; right kidney; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aspartic-type endopeptidase inhibitor activity; peptidase inhibitor activity; endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity; cysteine-type endopeptidase inhibitor activity;
Cellular component	extracellular region; extracellular exosome; extracellular space;
Biological process	negative regulation of peptidase activity; proteolysis; spermatogenesis; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	10406
	67701
	ENSG00000101443
	ENSMUSG00000017723
	Q14508
	Q9DAU7
	NM_006103; NM_080733; NM_080734; NM_080735; NM_080736
	NM_026323; NM_001374655
	NP_006094
	NP_080599; NP_001361584
	Wikidata
View/Edit Human	View/Edit Mouse

WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4 (HE4) - is a protein that in humans is encoded by the WFDC2 gene.

HE4 is a tumor marker of ovarian cancer, with 80% sensitivity at a cut-off of 150 pmol/L.