WFS1

WFS1
Identifiers
Aliases	WFS1, CTRCT41, WFRS, WFS, WFSL, wolframin ER transmembrane glycoprotein
External IDs	OMIM: 606201; MGI: 1328355; HomoloGene: 4380; GeneCards: WFS1; OMA:WFS1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	6,303,265 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	37,146,549 bp
RNA expression pattern
	Top expressed in
	right ovary; ; left ovary; ; body of uterus; ; nucleus accumbens; ; stromal cell of endometrium; ; popliteal artery; ; tibial arteries; ; ascending aorta; ; right lung; ; gastric mucosa;
	Top expressed in
	olfactory tubercle; ; nucleus accumbens; ; Region I of hippocampus proper; ; extraocular muscle; ; digastric muscle; ; thalamic reticular nucleus; ; plantaris muscle; ; aortic valve; ; superior frontal gyrus; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ATPase binding; protein binding; ubiquitin protein ligase binding; calcium-dependent protein binding; calmodulin binding; proteasome binding;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; integral component of endoplasmic reticulum membrane; dendrite; endoplasmic reticulum; proteasome complex; endoplasmic reticulum lumen; integral component of synaptic vesicle membrane;
Biological process	negative regulation of neuron apoptotic process; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; calcium ion homeostasis; glucose homeostasis; kidney development; protein stabilization; nervous system process; positive regulation of growth; negative regulation of transcription by RNA polymerase II; hearing; endoplasmic reticulum calcium ion homeostasis; protein maturation by protein folding; negative regulation of ATF6-mediated unfolded protein response; negative regulation of DNA-binding transcription factor activity; response to endoplasmic reticulum stress; ER overload response; IRE1-mediated unfolded protein response; ubiquitin-dependent ERAD pathway; renal water homeostasis; negative regulation of programmed cell death; positive regulation of protein ubiquitination; negative regulation of type B pancreatic cell apoptotic process; visual perception; positive regulation of calcium ion transport; pancreas development; endoplasmic reticulum unfolded protein response; olfactory behavior; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	7466
	22393
	ENSG00000109501
	ENSMUSG00000039474
	O76024
	P56695
	NM_006005; NM_001145853
	NM_011716
	NP_001139325; NP_005996
	NP_035846
	Wikidata
View/Edit Human	View/Edit Mouse

Wolframin is a protein that in humans is encoded by the WFS1 gene.