WHSC1L1

NSD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DAQ, 4GND, 4GNE, 4GNF, 4GNG, 4RXJ, 4YZ8, 2ND1, 2NCZ
Identifiers
Aliases	NSD3, pp14328, WHSC1L1, WHISTLE, Wolf-Hirschhorn syndrome candidate 1-like 1, nuclear receptor binding SET domain protein 3, KMT3G, KMT3F
External IDs	OMIM: 607083; MGI: 2142581; HomoloGene: 56960; GeneCards: NSD3; OMA:NSD3 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	38,382,272 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	26,209,694 bp
RNA expression pattern
	Top expressed in
	pylorus; ; epithelium of colon; ; ganglionic eminence; ; cardia; ; ventricular zone; ; entorhinal cortex; ; caput epididymis; ; sural nerve; ; nipple; ; lactiferous duct;
	Top expressed in
	hand; ; lacrimal gland; ; superior cervical ganglion; ; seminal vesicula; ; otic vesicle; ; granulocyte; ; human fetus; ; body of femur; ; parotid gland; ; otolith organ;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; protein binding; metal ion binding; histone-lysine N-methyltransferase activity; transcription coactivator activity; histone methyltransferase activity (H3-K36 specific);
Cellular component	nucleus; nucleoplasm; chromosome; chromatin;
Biological process	histone methylation; methylation; regulation of transcription, DNA-templated; transcription, DNA-templated; histone lysine methylation; chromatin organization; positive regulation of transcription, DNA-templated; positive regulation of histone H3-K36 trimethylation; histone H3-K36 methylation;
	Sources:Amigo / QuickGO
Orthologs
	54904
	234135
	ENSG00000147548
	ENSMUSG00000054823
	Q9BZ95
	Q6P2L6
	NM_017778; NM_023034
	NM_001001735; NM_001081269; NM_001308481; NM_001308482
	NP_060248; NP_075447
	NP_001001735; NP_001074738; NP_001295410; NP_001295411
	Wikidata
View/Edit Human	View/Edit Mouse

Histone-lysine N-methyltransferase NSD3 is an enzyme that in humans is encoded by the WHSC1L1 gene.

This gene is related to the Wolf–Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described.

The WHSC1L1 gene is amplified in several cancers, including lung cancer and head and neck cancer, and may play a role in carcinogenesis.