WIPF2

WIPF2
Identifiers
Aliases	WIPF2, WICH, WIRE, WAS/WASL interacting protein family member 2
External IDs	OMIM: 609692; MGI: 1924462; HomoloGene: 15777; GeneCards: WIPF2; OMA:WIPF2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,284,136 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,795,866 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; buccal mucosa cell; ; frontal pole; ; lower lobe of lung; ; nipple; ; Brodmann area 46; ; internal globus pallidus; ; Brodmann area 10; ; optic nerve; ; paraflocculus of cerebellum;
	Top expressed in
	transitional epithelium of urinary bladder; ; genital tubercle; ; subiculum; ; superior colliculus; ; ventral tegmental area; ; tail of embryo; ; central gray substance of midbrain; ; medial geniculate nucleus; ; Region I of hippocampus proper; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin binding; protein binding; actin filament binding;
Cellular component	cytoplasm; cytosol; cytoskeleton; nucleoplasm; plasma membrane; actin filament; actin cortical patch;
Biological process	Fc-gamma receptor signaling pathway involved in phagocytosis; actin cortical patch assembly; endocytosis; actin filament-based movement; positive regulation of actin nucleation; actin cortical patch localization;
	Sources:Amigo / QuickGO
Orthologs
	147179
	68524
	ENSG00000171475
	ENSMUSG00000038013
	Q8TF74
	Q6PEV3
	NM_133264
	NM_197940
	NP_573571
	NP_922922
	Wikidata
View/Edit Human	View/Edit Mouse

WAS/WASL-interacting protein family member 2 is a protein that in humans is encoded by the WIPF2 gene.

This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery.