WIPI protein family

The WIPI protein family (WD-repeat protein Interacting with PhosphoInositides) is an evolutionarily conserved family of proteins. WIPI proteins contain a WD repeat domain that folds into a 7-bladed beta-propeller that functions in autophagy, and contain a conserved motif for interaction with phospholipids.

Members of this family include:

ProteinGeneAliasesYeast
WIPI-1WIPI1WIPI49, FLJ10055Atg18
WIPI-2WIPI2Svp1a, DKFZP434J154 WIPI49-like protein 2Atg21
WIPI-3WDR45L628 protein, WIPI49-like protein
WIPI-4WDR45JM5 protein, WDRX1
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