WNK2

WNK2
Identifiers
Aliases	WNK2, NY-CO-43, P/OKcl.13, PRKSDCCAG43, WNK lysine deficient protein kinase 2
External IDs	OMIM: 606249; MGI: 1922857; HomoloGene: 19155; GeneCards: WNK2; OMA:WNK2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	93,320,572 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	49,301,490 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right uterine tube; ; right auricle of heart; ; right hemisphere of cerebellum; ; body of pancreas; ; transverse colon; ; anterior pituitary; ; ganglionic eminence; ; left ventricle; ; muscle layer of sigmoid colon;
	Top expressed in
	muscle of thigh; ; superior frontal gyrus; ; primary visual cortex; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; secondary oocyte; ; skeletal muscle tissue; ; lacrimal gland; ; Rostral migratory stream; ; triceps brachii muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; ATP binding; kinase activity; protein serine/threonine kinase activity; chloride channel inhibitor activity; potassium channel inhibitor activity;
Cellular component	cytoplasm; plasma membrane; membrane; cytosol;
Biological process	negative regulation of ERK1 and ERK2 cascade; protein autophosphorylation; protein phosphorylation; positive regulation of sodium ion transmembrane transporter activity; intracellular signal transduction; phosphorylation; negative regulation of cell population proliferation; positive regulation of canonical Wnt signaling pathway; ion homeostasis; negative regulation of sodium ion transport; positive regulation of ion transmembrane transporter activity; positive regulation of potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	65268
	75607
	ENSG00000165238
	ENSMUSG00000037989
	Q9Y3S1
	Q3UH66
	NM_001282394; NM_006648
	NM_001290311; NM_001290313; NM_029361
	NP_001269323; NP_006639
	NP_001277240; NP_001277242; NP_083637
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase WNK2 is an enzyme that in humans is encoded by the WNK2 gene.

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine.