Proto-oncogene Wnt-1

WNT1
Identifiers
Aliases	WNT1, BMND16, INT1, OI15, Wnt family member 1
External IDs	OMIM: 164820; MGI: 98953; HomoloGene: 3963; GeneCards: WNT1; OMA:WNT1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	48,982,620 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	98,691,718 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; nucleus accumbens; ; superior frontal gyrus; ; right frontal lobe; ; prefrontal cortex; ; putamen; ; blood; ; caudate nucleus; ; bone marrow; ; Brodmann area 9;
	Top expressed in
	muscle layer of urethra; ; pelvic part of vagina; ; rhombic lip; ; ejaculatory duct; ; perineal part of vagina; ; inner cell mass; ; epithelium of seminiferous tubule of testis; ; choroid plexus of fourth ventricle; ; female urethra; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; protein domain specific binding; frizzled binding; morphogen activity; signaling receptor binding; receptor ligand activity;
Cellular component	cytoplasm; endocytic vesicle membrane; endoplasmic reticulum lumen; plasma membrane; extracellular region; cell surface; Golgi lumen; extracellular exosome; extracellular space;
Biological process	negative regulation of cell-substrate adhesion; forebrain anterior/posterior pattern specification; dopaminergic neuron differentiation; neurogenesis; cell fate commitment; negative regulation of fat cell differentiation; positive regulation of protein phosphorylation; myotube differentiation; metencephalon development; midbrain-hindbrain boundary maturation during brain development; T cell differentiation in thymus; spinal cord association neuron differentiation; negative regulation of cell-cell adhesion; neuron fate determination; signal transduction in response to DNA damage; central nervous system morphogenesis; positive regulation of fibroblast proliferation; positive regulation of dermatome development; cell-cell signaling; negative regulation of cell differentiation; hematopoietic stem cell proliferation; cell proliferation in midbrain; positive regulation of DNA-binding transcription factor activity; embryonic axis specification; hepatocyte differentiation; negative regulation of transforming growth factor beta receptor signaling pathway; cerebellum development; ubiquitin-dependent SMAD protein catabolic process; cerebellum formation; negative regulation of BMP signaling pathway; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; positive regulation of transcription, DNA-templated; multicellular organism development; diencephalon development; branching involved in ureteric bud morphogenesis; cellular response to peptide hormone stimulus; midbrain-hindbrain boundary development; embryonic brain development; response to wounding; positive regulation of insulin-like growth factor receptor signaling pathway; inner ear morphogenesis; animal organ regeneration; positive regulation of cell population proliferation; negative regulation of ubiquitin-dependent protein catabolic process; neuron fate commitment; myoblast fusion; positive regulation of lamellipodium assembly; bone development; Spemann organizer formation; midbrain development; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; Wnt signaling pathway; astrocyte-dopaminergic neuron signaling; positive regulation of canonical Wnt signaling pathway; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; Wnt signaling pathway, planar cell polarity pathway; beta-catenin destruction complex disassembly; negative regulation of oxidative stress-induced neuron death; regulation of signaling receptor activity; canonical Wnt signaling pathway; negative regulation of apoptotic process; neuron differentiation;
	Sources:Amigo / QuickGO
Orthologs
	7471
	22408
	ENSG00000125084
	ENSMUSG00000022997
	P04628
	P04426
	NM_005430
	NM_021279
	NP_005421
	NP_067254
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene Wnt-1, or Proto-oncogene Int-1 homolog is a protein that in humans is encoded by the WNT1 (INT1) gene.

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.