WNT2

WNT2
Identifiers
Aliases	WNT2, INT1L1, IRP, Wnt family member 2
External IDs	OMIM: 147870; MGI: 98954; HomoloGene: 20719; GeneCards: WNT2; OMA:WNT2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	117,323,152 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	18,030,584 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; placenta; ; lower lobe of lung; ; upper lobe of left lung; ; testicle; ; right lung; ; gonad; ; visceral pleura; ; decidua; ; amniotic fluid;
	Top expressed in
	prostatic urethra; ; septum transversum; ; muscle layer of urethra; ; lamina propria of prostatic urethra; ; abdominal wall; ; left lung lobe; ; sinus venosus; ; umbilical cord; ; primordial ventricle; ; lamina propria of vagina;
	More reference expression data
	n/a
Gene ontology
Molecular function	frizzled binding; signaling receptor binding; cytokine activity; protein binding; receptor ligand activity;
Cellular component	cytoplasm; extracellular matrix; Wnt signalosome; plasma membrane; extracellular region; extracellular space; extrinsic component of external side of plasma membrane; collagen-containing extracellular matrix;
Biological process	positive regulation of mesenchymal cell proliferation; positive regulation of cardiac muscle cell proliferation; positive regulation of endothelial cell proliferation; mammary gland epithelium development; lung development; cell-cell signaling; multicellular organism development; positive regulation of DNA-binding transcription factor activity; neurogenesis; lens development in camera-type eye; cardiac epithelial to mesenchymal transition; lung induction; cellular response to retinoic acid; iris morphogenesis; cellular response to transforming growth factor beta stimulus; positive regulation of epithelial cell proliferation involved in lung morphogenesis; positive regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; cell fate commitment; labyrinthine layer blood vessel development; positive regulation of fibroblast proliferation; atrial cardiac muscle tissue morphogenesis; positive regulation of canonical Wnt signaling pathway; canonical Wnt signaling pathway; neuron differentiation; midbrain dopaminergic neuron differentiation; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; Wnt signaling pathway; regulation of signaling receptor activity; cell proliferation in midbrain;
	Sources:Amigo / QuickGO
Orthologs
	7472
	22413
	ENSG00000105989
	ENSMUSG00000010797
	P09544
	P21552
	NM_003391
	NM_023653
	NP_003382
	NP_076142
	Wikidata
View/Edit Human	View/Edit Mouse

Wingless-type MMTV integration site family, member 2, also known as WNT2, is a human gene.

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes that encode secreted signaling proteins involved in the Wnt signaling pathway. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.