WNT3A

WNT3A
Identifiers
Aliases	WNT3A, Wnt family member 3A
External IDs	OMIM: 606359; MGI: 98956; HomoloGene: 22528; GeneCards: WNT3A; OMA:WNT3A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	228,061,271 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	59,181,578 bp
RNA expression pattern
	Top expressed in
	placenta; ; right lung; ; upper lobe of left lung; ; olfactory zone of nasal mucosa; ; skin of leg; ; skin of abdomen; ; mucosa of esophagus; ; salivary gland; ; minor salivary glands; ; prostate;
	Top expressed in
	urethra; ; male urethra; ; epithelium of male urethra; ; ejaculatory duct; ; female urethra; ; vagina; ; muscle layer of seminal vesicle; ; prostatic epithelium; ; muscle layer of urethra; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; signaling receptor binding; co-receptor binding; frizzled binding; protein binding; transcription coactivator activity; receptor ligand activity;
Cellular component	endocytic vesicle membrane; endoplasmic reticulum lumen; extracellular region; cell surface; extracellular exosome; Wnt-Frizzled-LRP5/6 complex; early endosome membrane; plasma membrane; Golgi lumen; presynapse; extracellular space; synapse; glutamatergic synapse;
Biological process	somitogenesis; cellular response to retinoic acid; hemopoiesis; positive regulation of protein phosphorylation; Wnt signaling pathway involved in forebrain neuroblast division; positive regulation of skeletal muscle tissue development; positive regulation of receptor internalization; axis elongation involved in somitogenesis; positive regulation of collateral sprouting in absence of injury; mammary gland development; platelet activation; heart looping; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of protein localization to plasma membrane; cardiac muscle cell fate commitment; mesoderm development; cell proliferation in forebrain; positive regulation of mesodermal cell fate specification; negative regulation of fat cell differentiation; canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; regulation of microtubule cytoskeleton organization; negative regulation of dopaminergic neuron differentiation; cell proliferation in midbrain; in utero embryonic development; negative regulation of axon extension involved in axon guidance; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription, DNA-templated; regulation of axonogenesis; positive regulation of B cell proliferation; post-anal tail morphogenesis; positive regulation of cardiac muscle cell differentiation; negative regulation of neuron projection development; paraxial mesodermal cell fate commitment; negative regulation of neurogenesis; positive regulation of protein tyrosine kinase activity; positive regulation of DNA-binding transcription factor activity; extracellular matrix organization; positive regulation of neural precursor cell proliferation; synaptic vesicle recycling; osteoblast differentiation; skeletal muscle cell differentiation; COP9 signalosome assembly; dorsal/ventral neural tube patterning; positive regulation of protein binding; platelet aggregation; midbrain development; positive regulation of protein kinase activity; positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of hepatocyte proliferation; neurogenesis; spinal cord association neuron differentiation; axonogenesis; positive regulation of cytokine production; positive regulation of dermatome development; somatic stem cell division; positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation; axon guidance; multicellular organism development; determination of left/right symmetry; inner ear morphogenesis; positive regulation of cell population proliferation; regulation of cell differentiation; hippocampus development; negative regulation of heart induction by canonical Wnt signaling pathway; positive regulation of transcription by RNA polymerase II; anterior/posterior pattern specification; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; beta-catenin destruction complex disassembly; neuron differentiation; Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; positive regulation of gene expression; calcium ion transmembrane transport via low voltage-gated calcium channel; presynapse assembly; negative regulation of neuron death; positive regulation of core promoter binding; regulation of RNA biosynthetic process; regulation of signaling receptor activity; cell population proliferation; canonical Wnt signaling pathway; secondary palate development; cell fate commitment; modulation of chemical synaptic transmission; regulation of synapse organization; postsynapse to nucleus signaling pathway; regulation of presynapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	89780
	22416
	ENSG00000154342
	ENSMUSG00000009900
	P56704
	P27467
	NM_033131
	NM_009522
	NP_149122
	NP_033548
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene.

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have are critical in tissue homeostasis, embryonic development, and disease.