WNT4

WNT4
Identifiers
Aliases	WNT4, SERKAL, WNT-4, Wnt family member 4
External IDs	OMIM: 603490; MGI: 98957; HomoloGene: 22529; GeneCards: WNT4; OMA:WNT4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	22,143,969 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	137,027,037 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; decidua; ; beta cell; ; skin of thigh; ; palpebral conjunctiva; ; skin of abdomen; ; right ovary; ; left ovary; ; right adrenal cortex; ; skin of hip;
	Top expressed in
	inner renal medulla; ; male urethra; ; hair follicle; ; conjunctival fornix; ; esophagus; ; gastrula; ; corneal stroma; ; islet of Langerhans; ; transitional epithelium of ureter; ; vestibular membrane of cochlear duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription corepressor activity; signaling receptor binding; frizzled binding; receptor ligand activity;
Cellular component	cytoplasm; endocytic vesicle membrane; endoplasmic reticulum lumen; extracellular region; cell surface; extracellular exosome; plasma membrane; Golgi lumen; extracellular space; extracellular matrix;
Biological process	non-canonical Wnt signaling pathway; T cell differentiation in thymus; positive regulation of canonical Wnt signaling pathway; negative regulation of male gonad development; mesonephros development; androgen biosynthetic process; gamete generation; negative regulation of wound healing; metanephros development; cellular response to transforming growth factor beta stimulus; positive regulation of collagen biosynthetic process; mesonephric tubule development; cell fate commitment; mammary gland epithelium development; kidney development; negative regulation of cell differentiation; metanephric nephron morphogenesis; negative regulation of apoptotic signaling pathway; female sex determination; tube morphogenesis; smooth muscle cell differentiation; negative regulation of gene expression; female gonad development; positive regulation of transcription, DNA-templated; positive regulation of GTPase activity; branching involved in ureteric bud morphogenesis; kidney morphogenesis; nephron development; paramesonephric duct development; thyroid-stimulating hormone-secreting cell differentiation; hormone metabolic process; negative regulation of steroid biosynthetic process; tertiary branching involved in mammary gland duct morphogenesis; cell differentiation; male gonad development; positive regulation of aldosterone biosynthetic process; positive regulation of bone mineralization; anatomical structure development; somatotropin secreting cell differentiation; negative regulation of testicular blood vessel morphogenesis; metanephric mesenchymal cell differentiation; sex differentiation; metanephric nephron development; oocyte development; negative regulation of cell migration; positive regulation of osteoblast differentiation; renal vesicle formation; neuron differentiation; regulation of cell-cell adhesion; epithelial to mesenchymal transition; canonical Wnt signaling pathway; negative regulation of transcription, DNA-templated; branching morphogenesis of an epithelial tube; metanephric tubule formation; non-canonical Wnt signaling pathway via MAPK cascade; negative regulation of testosterone biosynthetic process; embryonic epithelial tube formation; positive regulation of cortisol biosynthetic process; positive regulation of dermatome development; cellular response to starvation; adrenal gland development; multicellular organism development; negative regulation of fibroblast growth factor receptor signaling pathway; renal vesicle induction; positive regulation of meiotic nuclear division; positive regulation of focal adhesion assembly; liver development; immature T cell proliferation in thymus; positive regulation of stress fiber assembly; mesenchymal to epithelial transition; Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway; protein localization to plasma membrane; regulation of signaling receptor activity; negative regulation of androgen biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	54361
	22417
	ENSG00000162552
	ENSMUSG00000036856
	P56705
	P22724
	NM_030761
	NM_009523
	NP_110388
	NP_033549
	Wikidata
View/Edit Human	View/Edit Mouse

WNT4 is a secreted protein that, in humans, is encoded by the WNT4 gene, found on chromosome 1. It promotes female sex development and represses male sex development. Loss of function may have consequences, such as female to male sex reversal.