WRAP53

WRAP53
Identifiers
Aliases	WRAP53, DKCB3, TCAB1, WDR79, WD repeat containing antisense to TP53
External IDs	OMIM: 612661; MGI: 2384933; HomoloGene: 9995; GeneCards: WRAP53; OMA:WRAP53 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,703,502 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,471,081 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; epithelium of bronchus; ; bronchial epithelial cell; ; testicle; ; pancreatic ductal cell; ; olfactory zone of nasal mucosa; ; ganglionic eminence; ; granulocyte; ; tibialis anterior muscle; ; mucosa of transverse colon;
	Top expressed in
	blastocyst; ; spermatocyte; ; embryo; ; embryo; ; epiblast; ; granulocyte; ; morula; ; ventricular zone; ; right kidney; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	chaperone binding; protein binding; telomerase RNA binding; RNA binding; identical protein binding; protein-containing complex binding;
Cellular component	Cajal body; telomerase holoenzyme complex; nucleus; nucleoplasm; cytoplasm; cytosol; nuclear body;
Biological process	telomerase RNA localization to Cajal body; positive regulation of establishment of protein localization to telomere; scaRNA localization to Cajal body; protein localization to Cajal body; positive regulation of telomerase activity; establishment of protein localization to telomere; telomere formation via telomerase; telomere maintenance via telomerase;
	Sources:Amigo / QuickGO
Orthologs
	55135
	216853
	ENSG00000141499
	ENSMUSG00000041346
	Q9BUR4
	Q8VC51
	NM_001143990; NM_001143991; NM_001143992; NM_018081
	NM_144824; NM_001364769
	NP_001137462; NP_001137463; NP_001137464; NP_060551
	NP_659073; NP_001351698
	Wikidata
View/Edit Human	View/Edit Mouse

WRAP53 (also known as WD40-encoding RNA antisense to p53) is a gene implicated in cancer development. The name was coined in 2009 to describe the dual role of this gene, encoding both an antisense RNA that regulates the p53 tumor suppressor and a protein involved in DNA repair, telomere elongation and maintenance of nuclear organelles Cajal bodies (Figure 1).