WWP2

WWP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Y07
Identifiers
Aliases	WWP2, AIP2, WWp2-like, WW domain containing E3 ubiquitin protein ligase 2
External IDs	OMIM: 602308; MGI: 1914144; HomoloGene: 48490; GeneCards: WWP2; OMA:WWP2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	69,941,741 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	108,285,227 bp
RNA expression pattern
	Top expressed in
	tibia; ; tendon of biceps brachii; ; ascending aorta; ; Descending thoracic aorta; ; sural nerve; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; pancreatic ductal cell; ; endothelial cell;
	Top expressed in
	facial skeleton; ; sphenoid bone; ; basisphenoid; ; splanchnocranium; ; thumb; ; membranous bone; ; index finger; ; phalanx of index finger; ; tunica media of zone of aorta; ; bones of pectoral girdle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription factor binding; ubiquitin-protein transferase activity; protein binding; transferase activity; ubiquitin protein ligase activity;
Cellular component	membrane; ubiquitin ligase complex; extracellular exosome; nucleus; cytoplasm; cytosol;
Biological process	regulation of membrane potential; regulation of ion transmembrane transport; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; negative regulation of DNA-binding transcription factor activity; negative regulation of gene expression; negative regulation of protein transport; regulation of potassium ion transmembrane transporter activity; viral entry into host cell; viral process; negative regulation of transcription, DNA-templated; negative regulation of transporter activity; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; ubiquitin-dependent protein catabolic process; protein K63-linked ubiquitination; extracellular transport; protein ubiquitination; protein polyubiquitination; positive regulation of protein catabolic process; negative regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	11060
	66894
	ENSG00000198373
	ENSMUSG00000031930
	O00308
	Q9DBH0
	NM_001270453; NM_001270454; NM_001270455; NM_007014; NM_199424
	NM_025830
	NP_001257382; NP_001257383; NP_001257384; NP_008945; NP_955456
	NP_080106
	Wikidata
View/Edit Human	View/Edit Mouse

NEDD4-like E3 ubiquitin-protein ligase WWP2 also known as atrophin-1-interacting protein 2 (AIP2) or WW domain-containing protein 2 (WWP2) is an enzyme that in humans is encoded by the WWP2 gene.