WW domain
| WW domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Structure of the human mitotic rotamase Pin1. | |||||||||
| Identifiers | |||||||||
| Symbol | WW | ||||||||
| Pfam | PF00397 | ||||||||
| InterPro | IPR001202 | ||||||||
| PROSITE | PDOC50020 | ||||||||
| SCOP2 | 1pin / SCOPe / SUPFAM | ||||||||
| CDD | cd00201 | ||||||||
| |||||||||
The WW domain (also known as the rsp5-domain or WWP repeating motif) is a modular protein domain that mediates specific interactions with protein ligands. This domain is found in a number of unrelated signaling and structural proteins and may be repeated up to four times in some proteins. Apart from binding preferentially to proteins that are proline-rich, with particular proline-motifs, [AP]-P-P-[AP]-Y, some WW domains bind to phosphoserine- and phosphothreonine-containing motifs.