William Leighton (disambiguation)
William Leighton was a composer and also MP for Much Wenlock.
William Leighton may also refer to:
- William T. Leighton, architect
 - William Leighton (Lord Mayor of London), Lord Mayor of London in 1806
 - William Allport Leighton, botanist
 - William Leighton (Poet), 19th Century writer of Sons of Godwin (1876), Change (1878), Shakespeare's Dream and Other Poems (1881), etc., and manager of a glass factory.
 - William Leighton Sr (glassmaker) - glassmaker and chemist who discovered a new formula for soda-lime glass in 1864 that revolutionized the American glassmaking industry