Clascoterone

Clascoterone
Clinical data
Trade names	Winlevi
Other names	CB-03-01; Breezula; 11-Deoxycortisol 17α-propionate; 17α-(Propionyloxy)-; deoxycorticosterone; 21-Hydroxy-3,20-dioxopregn-4-en-17-yl propionate
AHFS/Drugs.com	Monograph
License data	US DailyMed: Clascoterone;
Pregnancy; category	AU: D;
Routes of; administration	Topical
ATC code	D10AX06 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; US: ℞-only;
Identifiers
	IUPAC name [(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate;
CAS Number	19608-29-8;
PubChem CID	11750009;
DrugBank	DB12499;
ChemSpider	9924713;
UNII	XN7MM8XG2M;
KEGG	D11451;
ChEMBL	ChEMBL3590187;
CompTox Dashboard (EPA)	DTXSID10471883 ;
ECHA InfoCard	100.210.810
Chemical and physical data
Formula	C24H34O5
Molar mass	402.531 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)C(=O)CO;
	InChI InChI=1S/C24H34O5/c1-4-21(28)29-24(20(27)14-25)12-9-19-17-6-5-15-13-16(26)7-10-22(15,2)18(17)8-11-23(19,24)3/h13,17-19,25H,4-12,14H2,1-3H3/t17-,18+,19+,22+,23+,24+/m1/s1; Key:GPNHMOZDMYNCPO-PDUMRIMRSA-N;

Clascoterone, sold under the brand name Winlevi, is an antiandrogen medication which is used topically in the treatment of acne. The medication is used as a cream by application to the skin, for instance the face and scalp. Clascoterone is an antiandrogen, or antagonist of the androgen receptor (AR), the biological target of androgens such as testosterone and dihydrotestosterone. It shows minimal systemic absorption when applied to skin.

Clascoterone was developed by Cassiopea and was approved for medical use in the United States in August 2020. The US Food and Drug Administration (FDA) considers it to be a first-in-class medication.