Guanabenz

Guanabenz
Clinical data
Trade namesWytensin
AHFS/Drugs.comConsumer Drug Information
MedlinePlusa686003
ATC code
  • none
Pharmacokinetic data
Protein binding90%
Elimination half-life6 hours
Identifiers
  • 2-(2,6-dichlorobenzylidene)hydrazinecarboximidamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.023.410
Chemical and physical data
FormulaC8H8Cl2N4
Molar mass231.08 g·mol−1
3D model (JSmol)
  • Clc1cccc(Cl)c1\C=N\N=C(/N)N
  • InChI=1S/C8H8Cl2N4/c9-6-2-1-3-7(10)5(6)4-13-14-8(11)12/h1-4H,(H4,11,12,14)/b13-4+ Y
  • Key:WDZVGELJXXEGPV-YIXHJXPBSA-N Y
  (verify)

Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist that is selective to the alpha-2 adrenergic receptor. Guanabenz is used as an antihypertensive drug used in the treatment of high blood pressure (hypertension).

The most common side effects during guanabenz therapy are dizziness, drowsiness, dry mouth, headache and weakness.

Guanabenz can make one drowsy or less alert, therefore driving or operating dangerous machinery is not recommended.