XBP1

XBP1
Identifiers
Aliases	XBP1, TREB5, XBP-1, XBP2, TREB-5, X-box binding protein 1
External IDs	OMIM: 194355; MGI: 98970; HomoloGene: 3722; GeneCards: XBP1; OMA:XBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	28,800,597 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	5,475,893 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; trachea; ; islet of Langerhans; ; olfactory zone of nasal mucosa; ; right lobe of liver; ; bone marrow cells; ; tonsil; ; rectum; ; epithelium of bronchus; ; appendix;
	Top expressed in
	lacrimal gland; ; parotid gland; ; seminal vesicula; ; submandibular gland; ; epithelium of stomach; ; gastrula; ; islet of Langerhans; ; right lung lobe; ; lobe of prostate; ; vestibular membrane of cochlear duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	estrogen receptor binding; protein homodimerization activity; protease binding; protein binding; protein kinase binding; sequence-specific DNA binding; cis-regulatory region sequence-specific DNA binding; protein heterodimerization activity; chromatin DNA binding; ubiquitin protein ligase binding; DNA binding; DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; identical protein binding;
Cellular component	cytosol; membrane; integral component of membrane; nucleoplasm; integral component of endoplasmic reticulum membrane; endoplasmic reticulum membrane; cytoplasm; endoplasmic reticulum; nucleus;
Biological process	positive regulation of MHC class II biosynthetic process; positive regulation of protein phosphorylation; negative regulation of endoplasmic reticulum unfolded protein response; positive regulation of immunoglobulin production; muscle organ development; vascular endothelial growth factor receptor signaling pathway; phosphatidylinositol 3-kinase signaling; apoptotic process; regulation of transcription, DNA-templated; regulation of protein stability; glucose homeostasis; transcription, DNA-templated; cell growth; positive regulation of endothelial cell apoptotic process; response to unfolded protein; fatty acid biosynthetic process; protein transport; positive regulation of TOR signaling; exocrine pancreas development; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; cell differentiation; positive regulation of autophagy; cellular response to laminar fluid shear stress; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of B cell differentiation; negative regulation of transcription by RNA polymerase II; cellular response to fluid shear stress; organelle organization; regulation of autophagy; immune response; positive regulation of proteasomal protein catabolic process; positive regulation of plasma cell differentiation; positive regulation of T cell differentiation; positive regulation of endoplasmic reticulum unfolded protein response; positive regulation of histone methylation; lipid metabolism; epithelial cell maturation involved in salivary gland development; positive regulation of protein acetylation; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; autophagy; multicellular organism development; ATF6-mediated unfolded protein response; IRE1-mediated unfolded protein response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; epithelial cell maturation; cellular response to oxidative stress; cellular response to vascular endothelial growth factor stimulus; protein destabilization; cellular response to peptide hormone stimulus; positive regulation of transcription by RNA polymerase II; negative regulation of pathway-restricted SMAD protein phosphorylation; adipose tissue development; positive regulation of vascular associated smooth muscle cell migration; liver development; cellular triglyceride homeostasis; cholesterol homeostasis; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of lactation; cellular response to amino acid stimulus; angiogenesis; cellular response to glucose starvation; response to insulin-like growth factor stimulus; negative regulation of ERK1 and ERK2 cascade; fatty acid homeostasis; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of hepatocyte proliferation; sterol homeostasis; cellular response to interleukin-4; positive regulation of protein kinase B signaling; ubiquitin-dependent protein catabolic process; positive regulation of fat cell differentiation; negative regulation of apoptotic process; endothelial cell proliferation; transcription by RNA polymerase II; positive regulation of cell population proliferation; negative regulation of myotube differentiation; positive regulation of cell migration; endoplasmic reticulum unfolded protein response; cellular response to nutrient; cellular response to insulin stimulus; response to endoplasmic reticulum stress; positive regulation of vascular wound healing; positive regulation of angiogenesis; neuron development; cellular response to lipopolysaccharide; cellular response to fructose stimulus; cellular response to glucose stimulus; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; cellular response to leukemia inhibitory factor; positive regulation of protein import into nucleus; regulation of cell growth;
	Sources:Amigo / QuickGO
Orthologs
	7494
	22433
	ENSG00000100219
	ENSMUSG00000020484
	P17861
	O35426
	NM_005080; NM_001079539; NM_001393999; NM_001394000
	NM_001271730; NM_013842
	NP_001073007; NP_005071
	NP_001258659; NP_038870
	Wikidata
View/Edit Human	View/Edit Mouse

X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. The XBP1 gene is located on chromosome 22 while a closely related pseudogene has been identified and localized to chromosome 5. The XBP1 protein is a transcription factor that regulates the expression of genes important to the proper functioning of the immune system and in the cellular stress response.