XPC (gene)

XPC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2A4J, 2GGM, 2OBH, 2RVB
Identifiers
Aliases	XPC, RAD4, XP3, XPCC, p125, xeroderma pigmentosum, complementation group C, XPC complex subunit, DNA damage recognition and repair factor
External IDs	OMIM: 613208; MGI: 103557; HomoloGene: 3401; GeneCards: XPC; OMA:XPC - orthologs
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	91,492,870 bp
RNA expression pattern
	n/a
	Top expressed in
	granulocyte; ; Paneth cell; ; substantia nigra; ; right kidney; ; proximal tubule; ; conjunctival fornix; ; vestibular membrane of cochlear duct; ; external carotid artery; ; condyle; ; right lung lobe;
	More reference expression data
Gene ontology
Molecular function	DNA binding; heteroduplex DNA loop binding; bubble DNA binding; single-stranded DNA binding; damaged DNA binding; protein binding; protein-containing complex binding;
Cellular component	cytoplasm; plasma membrane; nucleoplasm; XPC complex; nucleolus; nucleotide-excision repair factor 2 complex; nucleus; mitochondrion; intracellular membrane-bounded organelle; nucleotide-excision repair complex;
Biological process	nucleotide-excision repair; regulation of mitotic cell cycle phase transition; nucleotide-excision repair, DNA damage recognition; mitotic intra-S DNA damage checkpoint signaling; cellular response to DNA damage stimulus; global genome nucleotide-excision repair; response to auditory stimulus; DNA mismatch repair; response to UV-B; UV-damage excision repair; DNA repair; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, DNA duplex unwinding;
	Sources:Amigo / QuickGO
Orthologs
	7508
	22591
	ENSG00000154767
	ENSMUSG00000030094
	Q01831
	P51612
	NM_001145769; NM_004628
	NM_009531
	NP_004619; NP_001341655; NP_001341656; NP_001341658; NP_001341659
	NP_033557
	Wikidata
View/Edit Human	View/Edit Mouse

Xeroderma pigmentosum, complementation group C, also known as XPC, is a protein which in humans is encoded by the XPC gene. XPC is involved in the recognition of bulky DNA adducts in nucleotide excision repair. It is located on chromosome 3.