XPO1

XPO1
Available structures
PDB	Ortholog search: C9JV99 PDBe C9JV99 RCSB
List of PDB id codes
	1W9C, 2L1L, 3GB8, 4BSM, 4BSN, 5DIS
Identifiers
Aliases	XPO1, CRM1, emb, exp1, exportin 1, CRM-1
External IDs	OMIM: 602559; MGI: 2144013; HomoloGene: 2554; GeneCards: XPO1; OMA:XPO1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	61,538,741 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	23,248,249 bp
RNA expression pattern
	Top expressed in
	tibia; ; ventricular zone; ; germinal epithelium; ; epithelium of nasopharynx; ; parietal pleura; ; visceral pleura; ; embryo; ; skin of hip; ; trabecular bone; ; palpebral conjunctiva;
	Top expressed in
	tail of embryo; ; primitive streak; ; genital tubercle; ; Gonadal ridge; ; dermis; ; abdominal wall; ; epiblast; ; human fetus; ; mandibular prominence; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; transporter activity; protein binding; RNA binding; structural constituent of nuclear pore; nuclear export signal receptor activity;
Cellular component	cytoplasm; Cajal body; nuclear membrane; membrane; intracellular membrane-bounded organelle; nuclear envelope; nucleoplasm; lamellae anulatae; nucleus; kinetochore; nucleolus; cytosol; host cell; protein-containing complex; ribonucleoprotein complex; intracellular anatomical structure;
Biological process	ribosomal small subunit export from nucleus; intracellular transport of virus; regulation of centrosome duplication; mRNA transport; regulation of mRNA stability; negative regulation of transcription by RNA polymerase II; protein export from nucleus; regulation of protein catabolic process; protein localization to nucleus; protein transport; ribosomal large subunit export from nucleus; intracellular protein transport; viral process; sister chromatid cohesion; ribosomal subunit export from nucleus; regulation of protein export from nucleus; ribosome biogenesis; transport; nucleocytoplasmic transport;
	Sources:Amigo / QuickGO
Orthologs
	7514
	103573
	ENSG00000082898
	ENSMUSG00000020290
	O14980
	Q6P5F9
	NM_003400
	NM_001035226; NM_134014
	NP_003391
	NP_001030303; NP_598775
	Wikidata
View/Edit Human	View/Edit Mouse

Exportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a eukaryotic protein that mediates the nuclear export of various proteins and RNAs.