XRCC1

XRCC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LQC, 1CDZ, 1XNA, 1XNT, 2D8M, 2W3O, 3K75, 3K77, 5E6Q
Identifiers
Aliases	XRCC1, RCC, X-ray repair complementing defective repair in Chinese hamster cells 1, X-ray repair cross complementing 1, SCAR26
External IDs	OMIM: 194360; MGI: 99137; HomoloGene: 31368; GeneCards: XRCC1; OMA:XRCC1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	43,580,473 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	24,272,865 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; tendon of biceps brachii; ; ganglionic eminence; ; oocyte; ; pituitary gland; ; anterior pituitary; ; right uterine tube; ; left ovary; ; right ovary; ; granulocyte;
	Top expressed in
	saccule; ; otic placode; ; otic vesicle; ; superior surface of tongue; ; gallbladder; ; internal carotid artery; ; ventricular zone; ; external carotid artery; ; epiblast; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	damaged DNA binding; enzyme binding; protein binding; DNA ligase activity; 3' overhang single-stranded DNA endodeoxyribonuclease activity; oxidized DNA binding;
Cellular component	nucleoplasm; ERCC4-ERCC1 complex; nucleus; nucleolus;
Biological process	single strand break repair; nucleotide-excision repair, DNA gap filling; transcription-coupled nucleotide-excision repair; response to hypoxia; response to organic substance; double-strand break repair via homologous recombination; cellular response to DNA damage stimulus; base-excision repair, DNA ligation; hippocampus development; DNA repair; double-strand break repair via nonhomologous end joining; negative regulation of protection from non-homologous end joining at telomere; telomeric DNA-containing double minutes formation; base-excision repair; negative regulation of protein ADP-ribosylation; positive regulation of DNA ligase activity; cerebellum morphogenesis; response to hydroperoxide; voluntary musculoskeletal movement; positive regulation of single strand break repair; replication-born double-strand break repair via sister chromatid exchange;
	Sources:Amigo / QuickGO
Orthologs
	7515
	22594
	ENSG00000073050
	ENSMUSG00000051768
	P18887
	Q60596
	NM_006297
	NM_009532; NM_001360168; NM_001360169; NM_001360170
	NP_006288
	NP_033558; NP_001347097; NP_001347098; NP_001347099
	Wikidata
View/Edit Human	View/Edit Mouse

DNA repair protein XRCC1, also known as X-ray repair cross-complementing protein 1, is a protein that in humans is encoded by the XRCC1 gene. XRCC1 is involved in DNA repair, where it complexes with DNA ligase III.