XRN1 (gene)

XRN1
Identifiers
Aliases	XRN1, SEP1, 5'-3' exoribonuclease 1, Xrn1
External IDs	OMIM: 607994; MGI: 891964; HomoloGene: 5894; GeneCards: XRN1; OMA:XRN1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	142,448,062 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	95,939,856 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; Achilles tendon; ; germinal epithelium; ; visceral pleura; ; parietal pleura; ; tibia; ; bone marrow cells; ; gingival epithelium; ; endothelial cell; ; palpebral conjunctiva;
	Top expressed in
	tail of embryo; ; cumulus cell; ; Rostral migratory stream; ; thymus; ; genital tubercle; ; zygote; ; pineal gland; ; secondary oocyte; ; vas deferens; ; granulocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein binding; nucleic acid binding; nuclease activity; exonuclease activity; hydrolase activity; RNA binding; G-quadruplex RNA binding; G-quadruplex DNA binding; 5'-3' exoribonuclease activity; telomerase RNA binding; 5'-3' exonuclease activity;
Cellular component	membrane; plasma membrane; nucleus; cytoplasm; cytosol; dendrite; soma; synapse; P-body;
Biological process	regulation of mRNA stability; rRNA catabolic process; nuclear mRNA surveillance; histone mRNA catabolic process; negative regulation of translation; response to testosterone; cellular response to cycloheximide; RNA phosphodiester bond hydrolysis, exonucleolytic; cellular response to puromycin; negative regulation of telomere maintenance via telomerase; nuclear-transcribed mRNA catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	54464
	24127
	ENSG00000114127
	ENSMUSG00000032410
	Q8IZH2
	P97789
	NM_001042604; NM_001282857; NM_001282859; NM_019001
	NM_011916; NM_001311130
	NP_001269786; NP_001269788; NP_061874
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

5′-3′ exoribonuclease 1 (Xrn1) is a protein that in humans is encoded by the XRN1 gene. Xrn1 hydrolyses RNA in the 5′ to 3′ direction.