YAF2

YAF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D9G
Identifiers
Aliases	YAF2, YY1 associated factor 2
External IDs	OMIM: 607534; MGI: 1914307; HomoloGene: 136401; GeneCards: YAF2; OMA:YAF2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	42,238,349 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	93,234,816 bp
RNA expression pattern
	Top expressed in
	right auricle of heart; ; Achilles tendon; ; gastrocnemius muscle; ; epithelium of colon; ; left ventricle; ; muscle of thigh; ; ventricular zone; ; sural nerve; ; ganglionic eminence; ; gonad;
	Top expressed in
	Region I of hippocampus proper; ; barrel cortex; ; epithelium of lens; ; retinal pigment epithelium; ; substantia nigra; ; Epithelium of choroid plexus; ; iris; ; prefrontal cortex; ; blood; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; transcription coactivator activity; transcription corepressor activity;
Cellular component	nucleus; cytosol; nucleoplasm;
Biological process	positive regulation of transcription, DNA-templated; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of G0 to G1 transition;
	Sources:Amigo / QuickGO
Orthologs
	10138
	67057
	ENSG00000015153
	ENSMUSG00000022634
	Q8IY57
	Q99LW6
NM_001012424; NM_001190977; NM_001190979; NM_001190980; NM_005748;
	NM_001320080
	NM_024189
	NP_001177906; NP_001177908; NP_001177909; NP_001307009; NP_005739
	NP_077151
	Wikidata
View/Edit Human	View/Edit Mouse

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.