Tyrosine-protein kinase Yes

YES1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HDA
Identifiers
Aliases	YES1, HsT441, P61-YES, Yes, c-yes, YES proto-oncogene 1, Src family tyrosine kinase
External IDs	OMIM: 164880; MGI: 99147; HomoloGene: 55900; GeneCards: YES1; OMA:YES1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	812,546 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	32,844,401 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; parotid gland; ; buccal mucosa cell; ; visceral pleura; ; gingival epithelium; ; parietal pleura; ; endothelial cell; ; corpus epididymis; ; lactiferous duct;
	Top expressed in
	lumbar spinal ganglion; ; cumulus cell; ; left lung lobe; ; tail of embryo; ; migratory enteric neural crest cell; ; seminal vesicula; ; Rostral migratory stream; ; genital tubercle; ; Gonadal ridge; ; zygote;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; transmembrane transporter binding; epidermal growth factor receptor binding; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein binding; enzyme binding; protein tyrosine kinase activity; signaling receptor binding; ATP binding; phosphotyrosine residue binding;
Cellular component	Golgi apparatus; membrane; focal adhesion; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; microtubule organizing center; actin filament; extracellular exosome; cytoskeleton; cytoplasm; cytosol; glutamatergic synapse; postsynaptic specialization, intracellular component;
Biological process	cellular response to transforming growth factor beta stimulus; cellular response to retinoic acid; cell differentiation; Fc-gamma receptor signaling pathway involved in phagocytosis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; ephrin receptor signaling pathway; T cell costimulation; cellular response to platelet-derived growth factor stimulus; protein phosphorylation; regulation of vascular permeability; regulation of cell population proliferation; positive regulation of peptidyl-tyrosine phosphorylation; peptidyl-tyrosine autophosphorylation; protein autophosphorylation; leukocyte migration; positive regulation of transcription by RNA polymerase II; innate immune response; cell migration; regulation of glucose transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	7525
	22612
	ENSG00000176105
	ENSMUSG00000014932
	P07947
	Q04736
	NM_005433
	NM_001205132; NM_001205133; NM_009535
	NP_005424
	NP_001192061; NP_001192062; NP_033561
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase Yes is a non-receptor tyrosine kinase that in humans is encoded by the YES1 gene.

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.