YME1L1

YME1L1
Identifiers
Aliases	YME1L1, FTSH, MEG4, PAMP, YME1L, YME1 like 1 ATPase, OPA11
External IDs	OMIM: 607472; MGI: 1351651; HomoloGene: 31996; GeneCards: YME1L1; OMA:YME1L1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	27,155,266 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	23,089,272 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; tibia; ; parietal pleura; ; visceral pleura; ; amniotic fluid; ; corpus epididymis; ; gingival epithelium; ; Epithelium of choroid plexus; ; tail of epididymis; ; caput epididymis;
	Top expressed in
	pineal gland; ; yolk sac; ; seminiferous tubule; ; spermatid; ; submandibular gland; ; tail of embryo; ; genital tubercle; ; seminal vesicula; ; Gonadal ridge; ; gastrula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metallopeptidase activity; peptidase activity; hydrolase activity; metalloendopeptidase activity; ATP binding; metal ion binding; nucleotide binding; protein binding; ATP-dependent peptidase activity;
Cellular component	integral component of membrane; mitochondrion; membrane; nuclear body; mitochondrial inner membrane;
Biological process	mitochondrion organization; proteolysis; cell population proliferation; protein quality control for misfolded or incompletely synthesized proteins; mitochondrial protein catabolic process; mitochondrial calcium ion transmembrane transport; negative regulation of apoptotic process; protein hexamerization; mitochondrial protein processing;
	Sources:Amigo / QuickGO
Orthologs
	10730
	27377
	ENSG00000136758
	ENSMUSG00000026775
	Q96TA2; Q5T8D2
	O88967
	NM_001253866; NM_014263; NM_139312; NM_139313
	NM_013771
	NP_001240795; NP_055078; NP_647473
	NP_038799
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-dependent metalloprotease YME1L1 is an enzyme that in humans is encoded by the YME1L1 gene. YME1L1 belongs to the AAA family of ATPases and mainly functions in the maintenance of mitochondrial morphology. Mutations in this gene would cause infantile-onset mitochondriopathy.