YWHAE

YWHAE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BR9, 3UAL, 3UBW
Identifiers
Aliases	YWHAE, 14-3-3E, HEL2, KCIP-1, MDCR, MDS, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
External IDs	OMIM: 605066; MGI: 894689; HomoloGene: 100743; GeneCards: YWHAE; OMA:YWHAE - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	1,400,222 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	75,656,671 bp
RNA expression pattern
	Top expressed in
	superior frontal gyrus; ; ventricular zone; ; primary visual cortex; ; prefrontal cortex; ; ganglionic eminence; ; corpus callosum; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; temporal lobe; ; Amygdala;
	Top expressed in
	somite; ; mandibular prominence; ; maxillary prominence; ; Gonadal ridge; ; habenula; ; dorsomedial hypothalamic nucleus; ; optic nerve; ; supraoptic nucleus; ; atrium; ; subiculum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transmembrane transporter binding; protein domain specific binding; protein-containing complex binding; histone deacetylase binding; potassium channel regulator activity; phosphoprotein binding; protein binding; MHC class II protein complex binding; protein heterodimerization activity; enzyme binding; phosphoserine residue binding; ubiquitin protein ligase binding; cadherin binding involved in cell-cell adhesion; RNA binding; calcium channel regulator activity; identical protein binding; cadherin binding; scaffold protein binding;
Cellular component	cytoplasm; cytosol; membrane; kinesin complex; focal adhesion; melanosome; axon; mitochondrion; extracellular exosome; cytoplasmic vesicle membrane; nucleus; plasma membrane; synapse; central region of growth cone; glutamatergic synapse;
Biological process	protein targeting; negative regulation of protein dephosphorylation; intracellular signal transduction; substantia nigra development; neuron migration; negative regulation of peptidyl-serine dephosphorylation; hippo signaling; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; G2/M transition of mitotic cell cycle; regulation of heart rate by hormone; regulation of potassium ion transmembrane transporter activity; cerebral cortex development; regulation of cellular response to heat; regulation of membrane repolarization; membrane organization; viral process; regulation of heart rate by cardiac conduction; membrane repolarization during cardiac muscle cell action potential; hippocampus development; cell-cell adhesion; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; MAPK cascade; regulation of G2/M transition of mitotic cell cycle; protein localization to nucleus; cellular response to heat; positive regulation of protein export from nucleus; regulation of cytosolic calcium ion concentration; ciliary basal body-plasma membrane docking; regulation of postsynaptic membrane neurotransmitter receptor levels; negative regulation of calcium ion transmembrane transporter activity; negative regulation of calcium ion export across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	7531
	22627
	ENSG00000274474; ENSG00000108953
	ENSMUSG00000020849
	P62258
	P62259
	NM_006761
	NM_009536
	NP_006752
	NP_033562
	Wikidata
View/Edit Human	View/Edit Mouse

14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.