Yadkin–Pee Dee River Basin

The Yadkin–Pee Dee River Basin (alternatively watershed or drainage basin) is a large river basin in the eastern United States, covering around 7,221 square miles, making it the second largest in the state of North Carolina. Its headwaters rise near Blowing Rock, North Carolina, and the basin drains to the Atlantic Ocean in Winyah Bay, east of Georgetown, South Carolina.

The majority of the basin is within the Piedmont geographical area of the United States, and South Carolina, and parts of the Appalachian Mountains, in North Carolina. It is part of the larger South Atlantic–Gulf Water Resource Region.