Ritodrine

Ritodrine
Clinical data
Pronunciation/ˈrtdrn/ RY-toh-dreen
Trade namesPre-Par, Utopar, Yutopar
Other namesDU-21220; 4-Hydroxy-β-hydroxy-N-(4-hydroxyphenylethyl)amphetamine; N-(4-Hydroxyphenylethyl)-4-hydroxynorephedrine
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration
By mouth, parenteral
ATC code
Legal status
Legal status
  • US: Discontinued
Pharmacokinetic data
Protein binding~56%
MetabolismHepatic, metabolites are inactive
Elimination half-life1.7–2.6 hours
Identifiers
  • 4-[2-[[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.043.512
Chemical and physical data
FormulaC17H21NO3
Molar mass287.359 g·mol−1
3D model (JSmol)
  • O[C@H](c1ccc(O)cc1)[C@@H](NCCc2ccc(O)cc2)C
  • InChI=1S/C17H21NO3/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13/h2-9,12,17-21H,10-11H2,1H3/t12-,17-/m0/s1 Y
  • Key:IOVGROKTTNBUGK-SJCJKPOMSA-N Y
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Ritodrine, formerly sold under the brand name Yutopar among others, is a tocolytic drug used to stop premature labor. It was withdrawn from the US market, according to the FDA Orange Book. It was available in oral tablets or as an injection and was typically used as the hydrochloride salt.

The drug acts as a selective β2-adrenergic receptor agonist.

It was first approved for medical use in the United States in 1984.