ZAP70

ZAP70
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XZ0, 1FBV, 1M61, 1U59, 2CBL, 2OQ1, 2OZO, 2Y1N, 3ZNI, 4A4B, 4A4C, 4K2R, 4XZ1
Identifiers
Aliases	ZAP70, SRK, STCD, STD, TZK, ZAP-70, zeta chain of T cell receptor associated protein kinase 70kDa, zeta chain of T cell receptor associated protein kinase 70, zeta chain of T-cell receptor associated protein kinase 70, IMD48, ADMIO2
External IDs	OMIM: 176947; MGI: 99613; HomoloGene: 839; GeneCards: ZAP70; OMA:ZAP70 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	97,739,862 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	36,821,899 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; blood; ; spleen; ; appendix; ; thymus; ; testicle; ; gallbladder; ; upper lobe of left lung; ; mucosa of transverse colon;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; white pulp; ; blood; ; left lobe of liver; ; morula; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; embryo; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein binding; protein tyrosine kinase activity; signaling receptor binding; ATP binding; phosphotyrosine residue binding;
Cellular component	cytoplasm; cytosol; membrane; cell-cell junction; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; T cell receptor complex; immunological synapse; membrane raft;
Biological process	positive regulation of T cell differentiation; T cell migration; positive regulation of calcium-mediated signaling; intracellular signal transduction; adaptive immune response; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; immune system process; T cell aggregation; beta selection; negative thymic T cell selection; protein phosphorylation; B cell activation; T cell differentiation; immune response; positive thymic T cell selection; peptidyl-tyrosine autophosphorylation; protein autophosphorylation; peptidyl-tyrosine phosphorylation; innate immune response; T cell receptor signaling pathway; thymic T cell selection; positive regulation of alpha-beta T cell differentiation; T cell activation; regulation of cell population proliferation; positive regulation of alpha-beta T cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	7535
	22637
	ENSG00000115085
	ENSMUSG00000026117
	P43403
	P43404
	NM_001079; NM_207519; NM_001378594
	NM_009539; NM_001289612; NM_001289765; NM_001289766
	NP_001070; NP_997402; NP_001365523
	NP_001276541; NP_001276694; NP_001276695; NP_033565
	Wikidata
View/Edit Human	View/Edit Mouse

ZAP-70 (Zeta-chain-associated protein kinase 70) is a protein normally expressed near the surface membrane of lymphocytes (T cells, natural killer cells, and a subset of B cells). It is most prominently known to be recruited upon antigen binding to the T cell receptor (TCR), and it plays a critical role in T cell signaling.

ZAP-70 was initially discovered in TCR-stimulated Jurkat cells, an immortal line of human T lymphocytes, in 1991. Its molecular weight is 70 kDa, and it is a member of the protein-tyrosine kinase family and is a close homolog of SYK. SYK and ZAP70 share a common evolutionary origin and split from a common ancestor in the jawed vertebrates. The importance of ZAP-70 in T cell activation was determined when comparing ZAP-70 expression in patients with SCID (severe combined immunodeficiency). ZAP-70 deficient individuals were found to have no functioning T cells in their peripheral blood, suggesting that ZAP-70 is a critical component of T cell activation and development.

ZAP-70 expression in B cells is correlated with the development of chronic lymphocytic leukemia (CLL).