ZBTB7B

ZBTB7B
Identifiers
Aliases	ZBTB7B, THPOK, ZBTB15, ZFP-67, ZFP67, ZNF857B, c-KROX, hcKROX, CKROX, zinc finger and BTB domain containing 7B
External IDs	OMIM: 607646; MGI: 102755; HomoloGene: 7605; GeneCards: ZBTB7B; OMA:ZBTB7B - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	155,018,523 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	89,302,083 bp
RNA expression pattern
	Top expressed in
	monocyte; ; mucosa of transverse colon; ; skin of abdomen; ; skin of leg; ; granulocyte; ; nipple; ; cardia; ; body of stomach; ; salivary gland; ; mucosa of pharynx;
	Top expressed in
	granulocyte; ; pyloric antrum; ; lip; ; neural layer of retina; ; tibiofemoral joint; ; esophagus; ; lens; ; yolk sac; ; muscle of thigh; ; gastric mucosa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; metal ion binding; nucleic acid binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding; protein homodimerization activity; histone deacetylase binding;
Cellular component	nucleus; nucleoplasm;
Biological process	multicellular organism development; ectoderm development; cell differentiation; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; regulation of CD4-positive, alpha-beta T cell differentiation; regulation of CD8-positive, alpha-beta T cell differentiation; positive regulation of transcription by RNA polymerase II; regulation of gene expression; negative regulation of T-helper 17 cell differentiation; lactation; positive regulation of gene expression; response to insulin; positive regulation of CD4-positive, alpha-beta T cell differentiation; negative regulation of CD8-positive, alpha-beta T cell differentiation; positive regulation of insulin receptor signaling pathway; positive regulation of brown fat cell differentiation; adaptive thermogenesis; positive regulation of SREBP signaling pathway; negative regulation of transcription by RNA polymerase II; NK T cell differentiation; negative regulation of gene expression; positive regulation of histone deacetylation; negative regulation of NK T cell proliferation; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	51043
	22724
	ENSG00000160685
	ENSMUSG00000028042
	O15156
	Q64321
NM_001252406; NM_001256455; NM_001377451; NM_001377452; NM_001377453;
	NM_001377454; NM_001377455
	NM_009565; NM_001355206; NM_001355211; NM_001355212
NP_001239335; NP_001243384; NP_001364380; NP_001364381; NP_001364382;
	NP_001364383; NP_001364384
	NP_033591; NP_001342135; NP_001342140; NP_001342141
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene. ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g. COL1A1; MIM 120150) and has a role in development.[supplied by OMIM]