ZC3H11A

ZC3H11A
Identifiers
Aliases	ZC3H11A, ZC3HDC11A, zinc finger CCCH-type containing 11A
External IDs	OMIM: 613513; MGI: 1917829; HomoloGene: 8888; GeneCards: ZC3H11A; OMA:ZC3H11A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	203,854,999 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; endometrium; ; lymph node; ; cerebellar hemisphere; ; Achilles tendon; ; right hemisphere of cerebellum; ; ventricular zone; ; skin of abdomen; ; pituitary gland; ; skin of leg;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; RNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; mRNA binding;
Cellular component	transcription export complex; nucleoplasm;
Biological process	poly(A)+ mRNA export from nucleus; mRNA transport; RNA export from nucleus; termination of RNA polymerase II transcription; mRNA 3'-end processing; mRNA export from nucleus; transport; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9877
	70579
	ENSG00000058673
	ENSMUSG00000102976; ENSMUSG00000116275
	O75152
	Q6NZF1
NM_014827; NM_001319238; NM_001319239; NM_001350261; NM_001350262;
	NM_001350263; NM_001350264; NM_001350265; NM_001350266
	NM_001276767; NM_144530; NM_001357228
NP_001306167; NP_001306168; NP_055642; NP_001337190; NP_001337191;
	NP_001337192; NP_001337193; NP_001337194; NP_001337195; NP_001363263; NP_001363264; NP_001363265; NP_001363266; NP_001363267; NP_001363268; NP_001363269; NP_001363270; NP_001363271; NP_001363272; NP_001363273; NP_001363274; NP_001363275; NP_001363276; NP_001363277; NP_001363278; NP_001363279; NP_001363280; NP_001363281; NP_001363282; NP_001363283; NP_001363284; NP_001363285; NP_001363286; NP_001363287; NP_001363288; NP_001363289; NP_001363290; NP_001363291; NP_001363292; NP_001363293; NP_001363294; NP_001363295; NP_001363296
	NP_001263696; NP_653113; NP_001344157
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger CCCH domain-containing protein 11A is a protein that in humans is encoded by the ZC3H11A gene. ZC3H11A is a part of the transcription export (TREX) complex and plays a role in exporting of mRNAs from nucleus to cytoplasm. It is considered as stress-induced nuclear protein and maintains mRNAs exporting when the cells are under stress. Loss of functioning of ZC3H11A gene in HeLa cells results in abortion of the replication of nuclear replicating viruses but not cytoplasmic replicating viruses. It is discovered that ZC3H11A is significant for viability and metabolic regulation of mouse embryo