ZC3H12A

ZC3H12A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3V32, 3V33, 3V34
Identifiers
Aliases	ZC3H12A, MCPIP, MCPIP1, dJ423B22.1, zinc finger CCCH-type containing 12A, Reg1, MCPIP-1
External IDs	OMIM: 610562; MGI: 2385891; HomoloGene: 11824; GeneCards: ZC3H12A; OMA:ZC3H12A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,484,377 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	125,021,633 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; skin of abdomen; ; gastric mucosa; ; olfactory zone of nasal mucosa; ; skin of leg; ; cartilage tissue; ; granulocyte; ; left uterine tube; ; upper lobe of left lung; ; minor salivary glands;
	Top expressed in
	granulocyte; ; lip; ; blood; ; jejunum; ; intestinal villus; ; duodenum; ; esophagus; ; thymus; ; muscle of thigh; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	miRNA binding; chromatin binding; metal ion binding; ribonuclease activity; protein binding; nuclease activity; endonuclease activity; mRNA binding; hydrolase activity; ribosome binding; mRNA 3'-UTR binding; mRNA 3'-UTR AU-rich region binding; DNA binding; RNA binding; endoribonuclease activity; exoribonuclease activity; thiol-dependent deubiquitinase; RNA stem-loop binding;
Cellular component	cytoplasm; nucleoplasm; cytoskeleton; nucleus; extrinsic component of endoplasmic reticulum membrane; endoplasmic reticulum; rough endoplasmic reticulum membrane; rough endoplasmic reticulum; P-body; membrane; cytoplasmic ribonucleoprotein granule; protein-containing complex;
Biological process	positive regulation of p38MAPK cascade; cellular response to virus; cell differentiation; positive regulation of cell death; positive regulation of autophagy; negative regulation of interleukin-6 production; positive regulation of lipid storage; negative regulation of macrophage activation; cellular response to tumor necrosis factor; negative regulation of gene expression; positive regulation of angiogenesis; negative regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of endothelial cell migration; multicellular organism development; protein deubiquitination; positive regulation of gene expression; positive regulation of reactive oxygen species metabolic process; protein complex oligomerization; angiogenesis; regulation of gene expression; positive regulation of protein import into nucleus; negative regulation by host of viral genome replication; negative regulation of tumor necrosis factor production; positive regulation of miRNA catabolic process; negative regulation of NF-kappaB transcription factor activity; positive regulation of defense response to virus by host; apoptotic process; RNA phosphodiester bond hydrolysis, endonucleolytic; immune system process; negative regulation of muscle cell apoptotic process; negative regulation of I-kappaB kinase/NF-kappaB signaling; transcription, DNA-templated; positive regulation of fat cell differentiation; positive regulation of transcription by RNA polymerase II; nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay; defense response to virus; cellular response to glucose starvation; nervous system development; negative regulation of cytokine production involved in inflammatory response; cellular response to sodium arsenite; regulation of transcription, DNA-templated; negative regulation of protein phosphorylation; cellular response to ionomycin; positive regulation of mRNA catabolic process; cellular response to lipopolysaccharide; cellular response to oxidative stress; RNA phosphodiester bond hydrolysis; negative regulation of nitric oxide biosynthetic process; cellular response to interleukin-1; positive regulation of protein deubiquitination; cellular response to chemokine; inflammatory response; 3'-UTR-mediated mRNA destabilization; negative regulation of cardiac muscle contraction; positive regulation of execution phase of apoptosis; RNA phosphodiester bond hydrolysis, exonucleolytic; cellular response to DNA damage stimulus; immune response-activating signal transduction; negative regulation of NIK/NF-kappaB signaling; T cell receptor signaling pathway; negative regulation of T-helper 17 cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	80149
	230738
	ENSG00000163874
	ENSMUSG00000042677
	Q5D1E8
	Q5D1E7
	NM_025079; NM_001323550; NM_001323551
	NM_153159
	NP_001310479; NP_001310480; NP_079355
	NP_694799
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger CCCH-type containing 12A is a protein in humans that is encoded by the ZC3H12A gene.

ZC3H12A (also known as MCPIP-1 and Regnase-1) is an MCP1 (CCL2; MIM 158105)-induced protein that plays an important role in cell differentiation, apoptosis and the regulation of inflammation.