ZC3HC1

ZC3HC1
Identifiers
Aliases	ZC3HC1, NIPA, HSPC216, zinc finger C3HC-type containing 1
External IDs	MGI: 1916023; HomoloGene: 32315; GeneCards: ZC3HC1; OMA:ZC3HC1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	130,051,451 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	30,391,027 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; oocyte; ; deltoid muscle; ; secondary oocyte; ; muscle of thigh; ; quadriceps femoris muscle; ; gastrocnemius muscle; ; gonad; ; vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	otic placode; ; morula; ; morula; ; saccule; ; otic vesicle; ; mandibular prominence; ; maxillary prominence; ; epiblast; ; ventricular zone; ; Gonadal ridge;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; protein binding; protein kinase binding; metal ion binding;
Cellular component	nuclear membrane; nucleus;
Biological process	cell cycle; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; protein ubiquitination; cell division;
	Sources:Amigo / QuickGO
Orthologs
	51530
	232679
	ENSG00000091732
	ENSMUSG00000039130
	Q86WB0
	Q80YV2
	NM_001282190; NM_001282191; NM_016478; NM_001363701
	NM_172735; NM_001311086
	NP_001269119; NP_001269120; NP_057562; NP_001350630
	NP_001298015; NP_766323
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear-interacting partner of ALK (NIPA), also known as zinc finger C3HC-type protein 1 (ZC3HC1), is a protein that in humans is encoded by the ZC3HC1 gene on chromosome 7. It is ubiquitously expressed in many tissues and cell types though exclusively expressed in the nuclear subcellular location. NIPA is a skp1 cullin F-box (SCF)-type ubiquitin E3 ligase (SCFNIPA) complex protein involved in regulating entry into mitosis. The ZC3HC1 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.