ZFP36

ZFP36
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4J8S
Identifiers
Aliases	ZFP36, G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36, ZFP36 ring finger protein
External IDs	OMIM: 190700; MGI: 99180; HomoloGene: 2558; GeneCards: ZFP36; OMA:ZFP36 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,409,412 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,079,678 bp
RNA expression pattern
	Top expressed in
	vena cava; ; gastric mucosa; ; left uterine tube; ; trachea; ; saphenous vein; ; cardia; ; nipple; ; gallbladder; ; upper lobe of left lung; ; right lung;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; left lobe of liver; ; ascending aorta; ; aortic valve; ; mesenteric lymph nodes; ; jejunum; ; left lung lobe; ; duodenum; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; C-C chemokine binding; 14-3-3 protein binding; metal ion binding; protein binding; single-stranded RNA binding; mRNA 3'-UTR AU-rich region binding; enzyme binding; mRNA binding; protein kinase binding; RNA binding; heat shock protein binding; RNA polymerase binding; mRNA 3'-UTR binding;
Cellular component	cytoplasm; cytoplasmic stress granule; nucleus; RISC-loading complex; ribonucleoprotein complex; Dcp1-Dcp2 complex; exosome (RNase complex); P-body; cytosol; CCR4-NOT complex;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; mRNA catabolic process; regulation of tumor necrosis factor production; negative regulation of transcription by RNA polymerase II; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; miRNA-mediated gene silencing by inhibition of translation; response to starvation; 3'-UTR-mediated mRNA stabilization; negative regulation of erythrocyte differentiation; cellular response to lipopolysaccharide; cellular response to tumor necrosis factor; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA; regulation of keratinocyte apoptotic process; regulation of keratinocyte proliferation; positive regulation of fat cell differentiation; cellular response to fibroblast growth factor stimulus; cellular response to granulocyte macrophage colony-stimulating factor stimulus; negative regulation of viral transcription; regulation of keratinocyte differentiation; response to wounding; positive regulation of gene silencing by miRNA; regulation of mRNA stability; MAPK cascade; cellular response to glucocorticoid stimulus; cellular response to epidermal growth factor stimulus; positive regulation of intracellular mRNA localization; p38MAPK cascade; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay; gene silencing; mRNA transport; 3'-UTR-mediated mRNA destabilization; negative regulation of polynucleotide adenylyltransferase activity; transport;
	Sources:Amigo / QuickGO
Orthologs
	7538
	22695
	ENSG00000128016
	ENSMUSG00000044786
	P26651
	P22893
	NM_003407
	NM_011756
	NP_003398
	NP_035886
	Wikidata
View/Edit Human	View/Edit Mouse

Tristetraprolin (TTP), also known as zinc finger protein 36 homolog (ZFP36), is a protein that in humans, mice and rats is encoded by the ZFP36 gene. It is a member of the TIS11 (TPA-induced sequence) family, along with butyrate response factors 1 and 2.

TTP binds to AU-rich elements (AREs) in the 3'-untranslated regions (UTRs) of the mRNAs of some cytokines and promotes their degradation. For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA. Mice deficient in TTP develop a complex syndrome of inflammatory diseases.