ZFYVE16

ZFYVE16
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3T7L
Identifiers
Aliases	ZFYVE16, PPP1R69, zinc finger FYVE-type containing 16
External IDs	OMIM: 608880; MGI: 2145181; HomoloGene: 8826; GeneCards: ZFYVE16; OMA:ZFYVE16 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	80,483,379 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	92,667,376 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; endothelial cell; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; pars reticulata; ; inferior olivary nucleus; ; superior vestibular nucleus; ; C1 segment; ; tibia; ; external globus pallidus;
	Top expressed in
	spermatocyte; ; genital tubercle; ; tail of embryo; ; spermatid; ; granulocyte; ; choroid plexus of fourth ventricle; ; ventricular zone; ; cumulus cell; ; urethra; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	1-phosphatidylinositol binding; protein binding; phosphatidylinositol-3,4,5-trisphosphate binding; metal ion binding;
Cellular component	endosome; early endosome; early endosome membrane; intracellular membrane-bounded organelle; membrane; cytoplasm; cytosol;
Biological process	regulation of endocytosis; endosomal transport; protein targeting to lysosome; BMP signaling pathway; signal transduction; vesicle organization;
	Sources:Amigo / QuickGO
Orthologs
	9765
	218441
	ENSG00000039319
	ENSMUSG00000021706
	Q7Z3T8
	Q80U44
	NM_001105251; NM_001284236; NM_001284237; NM_014733; NM_001349434
	NM_173392
	NP_001098721; NP_001271165; NP_001271166; NP_055548; NP_001336363
	NP_775568
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger FYVE domain-containing protein 16 is a protein that in humans is encoded by the ZFYVE16 gene.

The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule.

In melanocytic cells ZFYVE16 gene expression may be regulated by MITF.