ZHX2

ZHX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DMP, 3NAU
Identifiers
Aliases	ZHX2, AFR1, RAF, zinc fingers and homeoboxes 2
External IDs	OMIM: 609185; MGI: 2683087; HomoloGene: 8968; GeneCards: ZHX2; OMA:ZHX2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	122,974,510 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	57,703,228 bp
RNA expression pattern
	Top expressed in
	superficial temporal artery; ; dorsal motor nucleus of vagus nerve; ; saphenous vein; ; Skeletal muscle tissue of rectus abdominis; ; inferior olivary nucleus; ; internal globus pallidus; ; Skeletal muscle tissue of biceps brachii; ; right ventricle; ; caput epididymis; ; lactiferous duct;
	Top expressed in
	knee joint; ; triceps brachii muscle; ; vastus lateralis muscle; ; otolith organ; ; temporal muscle; ; utricle; ; skeletal muscle tissue; ; medial head of gastrocnemius muscle; ; granulocyte; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein binding; protein homodimerization activity; transcription corepressor activity; metal ion binding; identical protein binding; protein heterodimerization activity; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; cytosol; plasma membrane;
Biological process	regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; mRNA catabolic process; negative regulation of neuron differentiation; somatic stem cell population maintenance; transcription, DNA-templated; retinal bipolar neuron differentiation; nervous system development; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	22882
	387609
	ENSG00000178764
	ENSMUSG00000071757
	Q9Y6X8
	Q8C0C0
	NM_014943; NM_001362797
	NM_199449
	NP_055758; NP_001349726
	NP_955520
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc fingers and homeoboxes protein 2 is a protein that in humans is encoded by the ZHX2 gene.

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.