ZNF274

ZNF274
Identifiers
Aliases	ZNF274, HFB101, ZF2, ZKSCAN19, ZSCAN51, zinc finger protein 274
External IDs	OMIM: 605467; MGI: 2176229; HomoloGene: 129707; GeneCards: ZNF274; OMA:ZNF274 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	58,213,562 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	65,452,035 bp
RNA expression pattern
	Top expressed in
	left ovary; ; epithelium of colon; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; right ovary; ; sural nerve; ; right ventricle; ; retinal pigment epithelium; ; left ventricle; ; right uterine tube;
	Top expressed in
	genital tubercle; ; neural layer of retina; ; ventricular zone; ; retinal pigment epithelium; ; epiblast; ; tail of embryo; ; ciliary body; ; thymus; ; primitive streak; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; protein binding; transcription corepressor activity; metal ion binding; nucleic acid binding; chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleolus; intracellular anatomical structure; nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of histone H3-K9 trimethylation; negative regulation of nucleic acid-templated transcription; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	10782
	170936
	ENSG00000171606
	ENSMUSG00000021514
	Q96GC6
	Q921B4
	NM_001278734; NM_001278735; NM_016324; NM_016325; NM_133502
	NM_178364
	NP_001265663; NP_057408; NP_057409; NP_598009
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 274 is a protein that in humans is encoded by the ZNF274 gene.

This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals.