ZNF346

ZNF346
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MKD, 2MKN
Identifiers
Aliases	ZNF346, JAZ, Zfp346, zinc finger protein 346
External IDs	OMIM: 605308; MGI: 1349417; HomoloGene: 8073; GeneCards: ZNF346; OMA:ZNF346 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	177,081,189 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,134,825 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; buccal mucosa cell; ; ventricular zone; ; sural nerve; ; ganglionic eminence; ; tendon of biceps brachii; ; gonad; ; Achilles tendon; ; muscle of thigh; ; tibialis anterior muscle;
	Top expressed in
	tail of embryo; ; neural layer of retina; ; genital tubercle; ; spermatocyte; ; extraocular muscle; ; superior frontal gyrus; ; thymus; ; cerebellar cortex; ; muscle of thigh; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	enzyme binding; double-stranded RNA binding; zinc ion binding; p53 binding; protein binding; metal ion binding; nucleic acid binding; RNA binding; miRNA binding;
Cellular component	cytoplasm; nucleolus; nucleus;
Biological process	intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	23567
	26919
	ENSG00000113761
	ENSMUSG00000021481
	Q9UL40
	Q9R0B7
NM_001308213; NM_001308214; NM_001308215; NM_001308216; NM_001308218;
	NM_001308219; NM_001308221; NM_001308223; NM_012279; NM_001363713
	NM_012017
NP_001295142; NP_001295143; NP_001295144; NP_001295145; NP_001295147;
	NP_001295148; NP_001295150; NP_001295152; NP_036411; NP_001350642
	NP_036147; NP_001365863; NP_001365864
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival.