ZNF703

zinc finger protein 703
zinc finger protein 703
Identifiers
Symbol	ZNF703
NCBI gene	80139
HGNC	25883
RefSeq	NM_025069
Other data
Locus	Chr. 8 p12

ZNF703
Identifiers
Aliases	ZNF703, ZEPPO1, ZNF503L, ZPO1, NLZ1, zinc finger protein 703
External IDs	OMIM: 617045; MGI: 2662729; HomoloGene: 81391; GeneCards: ZNF703; OMA:ZNF703 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	37,700,019 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	27,471,489 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; nipple; ; muscle of thigh; ; gastrocnemius muscle; ; body of tongue; ; Skeletal muscle tissue of rectus abdominis; ; popliteal artery; ; tibial arteries; ; mucosa of transverse colon; ; pylorus;
	Top expressed in
	ankle joint; ; ankle; ; transitional epithelium of urinary bladder; ; internal carotid artery; ; lip; ; external carotid artery; ; adrenal gland; ; hair follicle; ; skin of external ear; ; brown adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; protein binding; nucleic acid binding;
Cellular component	cytoplasm; nuclear matrix; nucleus; protein-containing complex;
Biological process	positive regulation of mammary gland epithelial cell proliferation; regulation of transcription, DNA-templated; adherens junction assembly; positive regulation of cell migration; regulation of canonical Wnt signaling pathway; cellular response to estradiol stimulus; positive regulation of epithelial to mesenchymal transition; transcription, DNA-templated; mammary gland epithelial cell differentiation; regulation of cell cycle; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of homotypic cell-cell adhesion; positive regulation of cell population proliferation; negative regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	80139
	353310
	ENSG00000183779
	ENSMUSG00000085795
	Q9H7S9
	P0CL69
	NM_025069
	NM_001101502; NM_001110508
	NP_079345
	NP_001094972; NP_001103978
	Wikidata
View/Edit Human	View/Edit Mouse

ZNF703 is a gene which has been linked with the development of breast cancers. ZNF703 is contained within the NET/N1z family responsible for regulation of transcription essential for developmental growth especially in the hindbrain. Normal functions performed by ZNF703 include adhesion, movement and proliferation of cells. ZNF703 directly accumulates histone deacetylases at gene promoter regions but does not bind to functional DNA.

Following research by scientists at Cancer Research UK, it was the first oncogene discovery in the past six years.

ZNF703 is a part of 8p12 telomeric amplicon that is associated with Luminal B breast cancer. Recently, ZNF703 is identified as the driver of 8p12 locus amplification.

Patients diagnosed with luminal B cancer caused by ZNF703 typically have lower recovery and survival rates than other cancer types.

Drug resistance of ZNF703 has been displayed when patients are treated using anti-cancer drug Tamoxifen.