2010 San Marino Grand Prix| Race details |
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| Date | 5 September 2010 |
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| Official name | Gran Premio Aperol di San Marino e Riviera di Rimini |
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| Location | Misano World Circuit |
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| Course | - Permanent racing facility
- 4.226 km (2.626 mi)
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The 2010 San Marino and Rimini Riviera motorcycle Grand Prix was the twelfth round of the 2010 Grand Prix motorcycle racing season. It took place on the weekend of 3–5 September 2010 at the Misano World Circuit.
The event was marred by the death of Shoya Tomizawa from injuries sustained in a crash during the Moto2 race.