2021 Rolex Paris Masters – Singles

Singles
2021 Rolex Paris Masters
Champion Novak Djokovic
Runner-up Daniil Medvedev
Score4–6, 6–3, 6–3
Draw56 (7 Q / 4 WC )
Seeds16

Novak Djokovic defeated defending champion Daniil Medvedev in the final, 4–6, 6–3, 6–3 to win the singles tennis title at the 2021 Paris Masters. It was his record-extending sixth Paris Masters title and record-breaking 37th Masters 1000 title overall, surpassing Rafael Nadal's tally in the latter category. With his victory over Hubert Hurkacz in the semifinals, Djokovic also secured the year-end ATP No. 1 singles ranking for a record seventh time, breaking a tie with Pete Sampras in the process.

The second-round match between Carlos Alcaraz and Jannik Sinner marked their first encounter at the ATP Tour level or higher. Alcaraz upset Sinner in two close sets.