2022 European Athletics Championships – Women's 400 metres

The women's 400 metres at the 2022 European Athletics Championships was held over three rounds at the Olympiastadion in Munich, Germany, from 15 to 17 August 2022. It was the twentieth time this event was contested at the European Athletics Championships. Athletes could qualify by achieving the entry standard of 51.70 seconds, by receiving a wild card, or by virtue of their ranking.

Twenty-three athletes competed in round 1 on 15 August. Janet Richard set a Maltese record of 53.49 s. The three fastest athletes of each heat plus the next three fastest of the rest qualified for the semi-finals, where they were joined by the twelve highest-ranking athletes, who had a bye in round 1. Twenty-four athletes competed in the semi-finals on 16 August. The two fastest in each heat and the two fastest of the rest advanced to the final.

Eight athletes competed in the final on 17 August. Femke Bol of the Netherlands won the final race in a national record of 49.44 s. Natalia Kaczmarek of Poland finished in second place in 49.94 s and Anna Kiełbasińska of Poland placed third in 50.29 s. Outside the medals, Rhasidat Adeleke or Ireland set a national record of 50.53 seconds.