2022 US Open – Men's singles

Carlos Alcaraz defeated Casper Ruud in the final, 6–4, 2–6, 7–6^(7–1), 6–3 to win the men's singles tennis title at the 2022 US Open. It was his first major title. Alcaraz claimed the world No. 1 singles ranking for the first time with the win; Ruud, Rafael Nadal, Daniil Medvedev, and Stefanos Tsitsipas were also in contention for the top position. He saved a match point en route to the title, in the quarterfinals against rival Jannik Sinner. Alcaraz was the youngest men's major champion since Nadal at the 2005 French Open, the youngest US Open champion since Pete Sampras in 1990, the first man born in the 2000s to win a major singles title, and the youngest man to be ranked world No. 1, surpassing Lleyton Hewitt's record. At 23 hours and 39 minutes of play duration across his seven matches, Alcaraz spent the longest time on court in major history (a record later surpassed by Medvedev at the 2024 Australian Open).

Medvedev was the defending champion, but lost in the fourth round to Nick Kyrgios. Medvedev was the first man outside the Big Four to be the top seed at a major since Andy Roddick at the 2004 Australian Open.

Nadal was vying for a record-extending 23rd major singles title, but lost in the fourth round to Frances Tiafoe. Alongside Medvedev's loss at the same stage, that marked the first US Open since 2000 and the first major since the 2017 Australian Open with neither of the top two seeded men reaching the quarterfinals. This was also the four-time champion's final appearance at the US Open. Three-time champion Novak Djokovic withdrew prior to the tournament as he could not travel to the United States, due to not having complied with the federal government's vaccination policy for non-US citizens against COVID-19.

This marked the third consecutive US Open where a player claimed his first major title, after Dominic Thiem in 2020 and Medvedev in 2021. The quarterfinal line-up guaranteed a first-time major champion, while the semifinal line-up marked the first time all four players made their US Open semifinal debut since the inaugural edition in 1881. Tiafoe was the first American man to reach the semifinals since Roddick in 2006, the first African American man to do so since Arthur Ashe in 1972, and the first African American man to reach any major semifinal since MaliVai Washington in 1996. Sinner was the youngest man to reach the quarterfinals at all four majors since Djokovic in 2008.

This was the first edition of US Open to feature a 10-point tie-break, when the score reaches six games all in the deciding set. Pedro Cachin defeated Aljaž Bedene in the first round in the first main-draw 10-point tie-break at the US Open.