ACP2

ACP2
Identifiers
Aliases	ACP2, acid phosphatase 2, lysosomal, LAP
External IDs	OMIM: 171650; MGI: 87882; HomoloGene: 1217; GeneCards: ACP2; OMA:ACP2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,248,906 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,044,443 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of pancreas; ; right adrenal gland; ; left adrenal gland; ; right adrenal cortex; ; stromal cell of endometrium; ; jejunal mucosa; ; left adrenal cortex; ; mucosa of transverse colon; ; salivary gland;
	Top expressed in
	spermatocyte; ; medial dorsal nucleus; ; stroma of bone marrow; ; spermatid; ; dentate gyrus of hippocampal formation granule cell; ; choroid plexus of fourth ventricle; ; medial geniculate nucleus; ; ascending aorta; ; aortic valve; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; acid phosphatase activity;
Cellular component	integral component of membrane; lysosomal membrane; lysosome; lysosomal lumen; extracellular exosome; membrane;
Biological process	skeletal system development; lysosome organization; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	53
	11432
	ENSG00000134575
	ENSMUSG00000002103
	P11117
	P24638
NM_001131064; NM_001302489; NM_001302490; NM_001302491; NM_001302492;
	NM_001610; NM_001357016
	NM_007387; NM_001357067
NP_001289418; NP_001289419; NP_001289420; NP_001289421; NP_001601;
	NP_001343945
	NP_031413; NP_001343996
	Wikidata
View/Edit Human	View/Edit Mouse

Lysosomal acid phosphatase is an enzyme that in humans is encoded by the ACP2 gene.

Lysosomal acid phosphatase is composed of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes.